Effects of photobiomodulation in pain and articular degeneration in mice arthritis model
نویسندگان
چکیده
ABSTRACT BACKGROUND AND OBJECTIVES: Rheumatoid arthritis is a set of symmetrical inflammatory processes that affects the joints. Currently, drug therapy first choice for treatment disease, however it can cause serious side effects. In this context, photobiomodulation appears as potential resource treatment. Therefore, aim study was to analyze effects low intensity laser on pain and joint degeneration in model mice. METHODS: 24 mice were randomly divided into 4 groups with 6 animals each: SG, ZG, LG DG. Zymosan used induce arthritis. The hyperalgesia measured using Von frey test. For histological analysis, talocrural region samples collected. Low AsGa Laser equipment treatment, operating 904 ηm wavelength, F:1000 Hz, W:50 mW dose 1 J/cm2. RESULTS: There significant difference (p<0.05) all times evaluation SG group compared ZG group, presenting an altered threshold. evaluation, application (1 J/cm2) arthritic reduced analyzed scores (1.20 ± 0.20) showed statistical when (LG=1.20 0.20; ZG=3.80 0.20, p<0.05). CONCLUSION parameters described effective reducing promoting protective effect cartilage.
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ژورنال
عنوان ژورنال: BrJP
سال: 2021
ISSN: ['2595-3192', '2595-0118']
DOI: https://doi.org/10.5935/2595-0118.20210028